The Cardiac Secretome: New Players & Therapeutic Opportunities
Acute myocardial infarction is a cardiac emergency triggered by coronary artery thrombosis and occlusion. The adult mammalian heart has limited regenerative capacity. Ischemic tissue injury sustained during acute MI therefore leads to scar formation and heart failure. Effective tissue repair after MI involves a vigorous angiogenic response that commences in the infarct border zone and extends into the necrotic infarct core. Neovessel formation after MI mitigates scarring and worsening of heart function and may represent a therapeutic target. Monocytes and macrophages accumulating in the infarct region drive postinfarction angiogenesis by secreting proteins that impart signals to nearby endothelial cells expressing their cognate receptors. The full complexity of this intercellular cross-talk remains incompletely understood. During my talk, I will provide several examples how decoding these signals has informed new therapeutic strategies to lower the risk of heart failure after MI.
This will be a hybrid seminar held at the IEKM seminar room, 1st floor, Elsässer Str. 2Q.
Prior registration is required – please contact info@sfb1425.uni-freiburg.de.
