Microtubules in Cardiac Health and Disease
Lucie Carrier, PhD, is a professor of “Functional Genomics of Cardiomyopathies” and team leader in the Department of Experimental Pharmacology and Toxicology, at the University Medical Center Hamburg-Eppendorf, Germany. Lucie Carrier is best known for her work on genetics and pathophysiology of hypertrophic cardiomyopathy, including the elucidation of the pathomechanisms of mutations in MYBPC3, encoding cardiac myosin-binding protein C, and for the contribution of the ubiquitin-proteasome system and autophagy-lysosomal pathway. Her recent research interests are the individualized medicine with human iPSCs, CRISPR/Cas9 genetic tools and engineered heart tissues, modified microtubules, and MYBPC3 and other gene replacement therapies in iPSC-derived cardiomyocytes and engineered heart tissues and animal models of inherited cardiomyopathy. More recently, together with Ben Prosser, UPenn, Philadelphia, they created and received a transatlantic network of excellence from the Leducq Foundation on “Cytoskeleton regulation of cardiomyocyte homeostasis in health and disease”. Lucie Carrier will give an overview on the microtubule function and modifications in cardiac health and disease and present unpublished data on the beneficial effect of activation of microtubule tyrosination on heart function in a mouse model of hypertrophic cardiomyopathy and in several models of iPSC-derived cardiomyocytes and engineered heart tissues.
